ReportBio RA1003 Anti-GAPDH Recombinant Rabbit Monoclonal Antibody

产品描述：Has both glyceraldehyde-3-phosphate dehydrogenase and nitrosylase activities, thereby playing a role in glycolysis and nuclear functions, respectively. Participates in nuclear events including transcription, RNA transport, DNA replication and apoptosis. Nuclear functions are probably due to the nitrosylase activity that mediates cysteine S-nitrosylation of nuclear target proteins such as SIRT1, HDAC2 and PRKDC. Modulates the organization and assembly of the cytoskeleton. Facilitates the CHP1-dependent microtubule and membrane associations through its ability to stimulate the binding of CHP1 to microtubules. Glyceraldehyde-3-phosphate dehydrogenase is a key enzyme in glycolysis that catalyzes the first step of the pathway by converting D-glyceraldehyde 3-phosphate (G3P) into 3-phospho-D-glyceroyl phosphate. Component of the GAIT (gamma interferon-activated inhibitor of translation) complex which mediates interferon-gamma-induced transcript-selective translation inhibition in inflammation processes. Upon interferon-gamma treatment assembles into the GAIT complex which binds to stem loop-containing GAIT elements in the 3'-UTR of diverse inflammatory mRNAs (such as ceruplasmin) and suppresses their translation.

产品名称       Anti-GAPDH Recombinant Rabbit Monoclonal Antibody 

分子量          36 kDa

种属反应性   Human,Mouse,Rat, Zebrafish

验证应用      WB,ICC/IF,IHC-P,IP,FC

抗体类型      重组兔单抗

免疫原          Recombinant protein within mouse GAPDH aa 94-333 / 333.

偶联             Non-conjugated

形态             Liquid

存放说明      Store at +4℃ after thawing. Aliquot store at -20℃ or -80℃. Avoid repeated freeze / thaw cycles.

存储缓冲液   1*TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.

亚型               IgG

纯化方式      Protein A affinity purified.

亚细胞定位   Cytoplasm, Nucleus, Membrane